Cannabidiol (CBD) Prevents Palmitic Acid-Induced Drop in Mitochondrial Membrane Potential

Gallily, R. and Yekhtin, Z. and Tarshis, M. and Sionov, R. Vogt (2019) Cannabidiol (CBD) Prevents Palmitic Acid-Induced Drop in Mitochondrial Membrane Potential. Pharmacology & Pharmacy, 10 (09). pp. 387-395. ISSN 2157-9423

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Abstract

Exposure of macrophages and microglia cells to the saturated palmitic acid (PA) leads to reduction in the mitochondrial membrane potential (), shrinkage of the cells and apoptosis. Here we show that the Cannabis component Cannabidiol (CBD) rescues both macrophages and microglia cells from the detrimental effects of PA. CBD prevents the shrinkage in cell size and the reduction incaused by PA. The protective effect of CBD on the macrophage mitochondria is important for sustaining the macrophage population even under the immunosuppressed conditions caused by this drug. To a similar extent, the antagonistic effect of CBD on PA-mediated microglia cytotoxicity is important for its role in neuroprotection.

Item Type: Article
Subjects: STM One > Chemical Science
Depositing User: Unnamed user with email support@stmone.org
Date Deposited: 22 Feb 2023 09:11
Last Modified: 23 Apr 2025 12:50
URI: http://note.send2pub.com/id/eprint/305

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